International Journal of Nephrology and Acute Disease

Creatinine Formation and Inorg-As Biotransformation: Influence of Trace Elements

Uttam K Chowdhury

Recently, a study showed that urinary creatinine concentrations (mg/L) were positively and significantly correlated with As concentrations, expressed as μg/L in urine (UAs) for both females and males1. The urinary creatinine concentrations were also positively correlated with As concentrations expressed as μg/L in blood1. Other researchers also reported that urinary creatinine concentrations were positively correlated with UAs concentrations expressed as μg/L2,3. These results suggest that creatinine may influence the release of arsenic from the body with unknown mechanisms or maybe there is a correlation between the formation of creatinine and arsenic metabolism. Chowdhury UK (2021)4 found the important results that adjusted urinary Se, Mn, and Hg concentrations expressed as ug/g cre were significantly and negatively correlated with urinary creatinine for both sexes. He also found a statistically significant and positive correlation between Mn and Hg in urine for both females and males (data not shown). Other studies reported that the combination of Mn and Hg might be more injurious to the brain, perhaps due to their synergistic effect5. The effect of Hg administered or exposed on renal dysfunction has been reported6-8. Selenium intoxication with selenite broth resulting in acute renal failure has also been reported9. Therefore, Se, Mn, and/ or Hg may have inhibitory effects in renal function and forming less creatinine when increasing Se, Mn, and/or Hg concentrations